About 100 minutes from Sapporo
Hokkaido Expressway (Sapporo-minami IC) - Tomakomai-higashi IC - Hidaka Expressway (Hidaka-Tomikawa IC) - National Route 237
About 60 minutes from New Chitose Airport
Hokkaido Expressway (New Chitose Airport IC) - Tomakomai-higashi IC - Hidaka Expressway (Hidaka-Tomikawa IC) - National Route 237
JR Sapporo Station - JR Tomakomai Station - Donan Bus (Tomakomai Ekimae stop to Biratori)
JR Sapporo Station - JR Tomakomai Station - JR Mukawa Station - Rail-replacement Bus - alight at Tomikawa Ekimae stop and transfer to local bus (Donan Bus)
Take the Express Pegasus-go from Sapporo Ekimae - Alight at Tomikawa Omachi - Take local bus (Donan Bus) from Tomikawa Omachi or Tomikawa Minami
Note: City buses run infrequently, and there are many different routes, so be sure to check the timetable carefully before boarding.
Donan Bus:https://www.donanbus.co.jp/
and Industry Section